Luprodex® (Leuprolide Acetate)

Luprodex® (Leuprolide Acetate) Leuprolide acetate 3.75 mg (Depot) and Leuprolide acetate 11.25 mg (3-month Depot) and Leuprolide acetate 22.5 mg (3-month Depot) Depot Injection — Leuprolide Depot by Bharat Serums and Vaccines: A Sourcing Guide for Hospitals and Oncology Pharmacies

Luprodex® is a brand of leuprolide acetate for injection (depot), a gonadotropin-releasing hormone (GnRH) agonist, manufactured in India by Bharat Serums and Vaccines Limited. According to the US prescribing information for the same active ingredient in depot form (Lupron Depot®), leuprolide acetate depot is indicated for advanced prostate cancer, and the lower strengths for endometriosis and uterine fibroids with iron therapy. Indications for Luprodex in India are defined by its approved pack insert and the Indian regulator. The decision to prescribe leuprolide acetate, including patient selection, dose and monitoring, rests entirely with the treating physician. This page provides sourcing and procurement information for hospitals and pharmacies, not clinical or treatment guidance.

As both a trusted medicine distributor in Delhi and a licensed pharmaceutical distributor in Delhi, A.K. Pharma supplies genuine Luprodex® (leuprolide acetate) Leuprolide acetate 3.75 mg (Depot) and Leuprolide acetate 11.25 mg (3-month Depot) and Leuprolide acetate 22.5 mg (3-month Depot) depot injection to hospitals, oncology centres and pharmacies across India. Buyers comparing pharmaceutical distribution companies and wholesale pharmaceutical distributors can also browse our full product range and the cancer medicines category. Supply is in bulk/wholesale quantities only.

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What is Luprodex (Leuprolide Acetate)?

Luprodex contains leuprolide acetate, a synthetic GnRH agonist supplied as a lyophilised depot powder with a 2 mL ampoule of diluent, for intramuscular or subcutaneous use as printed on the carton. The Luprodex Depot cartons list 11.25 mg and 22.5 mg (3-month depot) and 3.75 mg strengths.

How it works, according to the label: The reference label describes leuprolide acetate as a GnRH agonist that, given continuously, suppresses pituitary gonadotropins and lowers sex-hormone levels, with a temporary rise in testosterone (tumor flare) in the first weeks in prostate cancer.

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Indications as Listed in the Reference Label

The current US prescribing information for undefined (DailyMed) lists the following. Indications in India may differ and are defined by the Indian regulator and the Luprodex pack insert.

• Per the Lupron Depot labels for the same active ingredient: advanced prostate cancer (depot strengths for 1-, 3-, 4- and 6-month administration)
• Per the Lupron Depot 3.75 mg and 11.25 mg labels: management of endometriosis, including pain relief and reduction of endometriotic lesions
• Per the same labels: use with iron therapy for preoperative hematologic improvement of women with anemia caused by uterine fibroids
• The endometriosis labels state a limit on total duration of therapy because of bone mineral density concerns
• The indications and approved strengths for Luprodex itself are those in the Luprodex pack insert and the Indian regulator’s approval

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Clinical Studies and Evidence

The reference Lupron Depot labels summarise open-label studies in advanced prostate cancer that measured suppression of serum testosterone to castrate range (the 22.5 mg label reports castrate-range suppression within 30 days in 87 of 92 patients) and, for the lower strengths, controlled studies in endometriosis in which monthly 3.75 mg for six months was comparable to danazol. Luprodex is a different manufacturer’s product; its own pack insert and Indian approval govern. Full results are in the DailyMed prescribing information. Evidence is cited for information only and is not a recommendation for any patient.

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Available Strengths and Packs

Strength	Dosage form	Pack size (as shown on the carton)
Leuprolide acetate 3.75 mg (Depot)	Lyophilised powder for injection with diluent	1 vial + 1 ampoule (please confirm)
Leuprolide acetate 11.25 mg (3-month Depot)	Lyophilised powder for injection with diluent	1 vial + 1 x 2 mL ampoule
Leuprolide acetate 22.5 mg (3-month Depot)	Lyophilised powder for injection with diluent	1 vial + 1 x 2 mL ampoule

Please confirm the current pack and batch with us before ordering. Dose and regimen must be determined and followed exactly as directed by the treating physician and the approved prescribing information.

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Key Benefits for Procurement

• Genuine, sealed original-pack stock sourced through authorised channels
• Multiple strengths of one brand available from a single source
• Batch and expiry details provided on request
• Careful handling and storage of stock before dispatch
• Documentation support for hospital purchase departments

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Who Is This Page For?

This page is written for hospital pharmacists, oncology, urology and gynaecology department buyers, and pharmacies that source specialty hormonal injections. Leuprolide depot is administered by a healthcare provider, as described in the prescribing information.

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Possible Side Effects Reported in the Label

The Lupron Depot labels list warnings including tumor flare in prostate cancer (a temporary rise in testosterone in the first weeks), metabolic changes such as hyperglycemia, diabetes and hyperlipidemia, increased cardiovascular risk (myocardial infarction, sudden cardiac death, stroke), loss of bone mineral density with the endometriosis strengths, severe cutaneous adverse reactions, and embryo-fetal toxicity. This list is not complete; the full prescribing information governs.

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Precautions

• The label lists hypersensitivity to GnRH, GnRH agonists or any excipient as a contraindication.
• The 3.75 mg and 11.25 mg labels state that the two strengths have different release characteristics and are dosed differently, and must not be substituted for each other.
• The label states the product may cause fetal harm and describes the need to exclude pregnancy, as determined by the treating physician.
• The label describes monitoring for metabolic and bone-density changes, as determined by the treating physician.
• All use should follow the approved prescribing information and the instructions of the treating physician.

All use should follow the approved prescribing information and the instructions of the treating physician.

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Storage and Handling

Please follow the storage instructions printed on the Luprodex carton and leaflet. For reference, the US Lupron Depot labels describe storage at controlled room temperature, 20°C to 25°C. Keep in the original pack, out of reach of children.

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Manufacturer Information

Luprodex is marketed by Bharat Serums and Vaccines. A.K. Pharma is a licensed distributor and does not manufacture the product. As one of the pharmaceutical distributors serving Indian hospitals, we source Luprodex through authorised channels and supply it with pack and batch details. Buyers comparing a pharmaceutical wholesale distributors list or a pharma distribution company can verify our credentials on the About Us page.

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• Calutide® (Bicalutamide)
• Cytotam® (Tamoxifen)
• Capegard® (Capecitabine)
• Cytoplatin® (Cisplatin)
• Cabozanib® (Cabozantinib)
• Jakavi® (Ruxolitinib)
• Furmecil® (Tegafur/Gimeracil/Oteracil)
• All cancer medicines
• Patient Assistance Program

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Frequently Asked Questions

Is Luprodex available in India?
A.K. Pharma supplies Luprodex (leuprolide acetate) Leuprolide acetate 3.75 mg (Depot) and Leuprolide acetate 11.25 mg (3-month Depot) and Leuprolide acetate 22.5 mg (3-month Depot) depot injection to hospitals and pharmacies in India. Contact us for current availability.

What does Luprodex contain?
Leuprolide acetate, a GnRH agonist, as a depot injection in 3.75 mg, 11.25 mg and 22.5 mg strengths, manufactured by Bharat Serums and Vaccines.

Can I order a single pack?
A.K. Pharma is a distributor and supplies bulk/wholesale quantities only, not one or two pieces.

How should Luprodex be stored?
As printed on the carton and leaflet, in the original pack. The US Lupron Depot label describes controlled room temperature.

Does A.K. Pharma advise on dosing or suitability?
No. Treatment decisions, including dosing, rest solely with the treating physician and the approved prescribing information.

How do I request a quote?
Call or WhatsApp us, or use the contact details below.

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Why Order from A.K. Pharma

• Licensed pharmaceutical distributor in Delhi with 25+ years in specialty medicines
• Genuine, original-pack stock
• Bulk/wholesale supply to hospitals, oncology centres and pharmacies
• Batch and expiry details on request
• Dedicated team for hospital procurement queries

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Sources and Further Reading

• Lupron Depot (prostate cancer strengths) prescribing information, DailyMed
• Lupron Depot 3.75 mg prescribing information, DailyMed
• Lupron Depot 11.25 mg prescribing information, DailyMed
• National Cancer Institute: leuprolide acetate
• MedlinePlus: Leuprolide Injection
• National Cancer Institute: hormone therapy

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Contact A.K. Pharma for Luprodex Supply

📍 E-2/257A, 2nd Floor, Shastri Nagar, New Delhi 110052
📞 011 4172 6999
📱 WhatsApp: +91 9810034827
🌐 akpharma.in

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Disclaimer: This page is intended for informational and sourcing/procurement purposes only and does not constitute medical or clinical advice. A.K. Pharma is a licensed medicine distributor, not a healthcare provider, and does not provide clinical guidance. All treatment decisions, including drug selection and dosing, rest solely with the treating physician and should follow the approved prescribing information.