Alprostadil 125mcg & 250mcg Injection — Prostaglandin E1 for Neonatal Cardiac Care, Peripheral Arterial Disease, and Urology
Prostaglandin E1 Injection for Hospital and Institutional Use
A Sourcing Guide for Hospitals, NICUs, and Specialist Centres
Endoprost® (Alprostadil) is a synthetic Prostaglandin E1 (PGE1) injection used across multiple hospital specialties — primarily in neonatal intensive care units for ductal-dependent congenital heart disease, in vascular surgery for peripheral arterial disease, and in urology for erectile dysfunction refractory to oral therapy. Clinical decisions regarding its use rest entirely with the treating physician in accordance with the approved prescribing information. This page provides sourcing and procurement information for hospitals and institutional pharmacies, not clinical or treatment guidance.
As a trusted medicine distributor in Delhi and a licensed pharmaceutical distributor in Delhi, A.K. Pharma supplies genuine Endoprost (Alprostadil) 125mcg and 250mcg injections to hospitals, NICUs, nursing homes, and specialist centres across India, manufactured by Bharat Serum and Vaccines. Hospitals managing broader specialty caseloads can also source companion medicines through A.K. Pharma’s full product range.
Endoprost contains Alprostadil, a synthetic analogue of naturally occurring Prostaglandin E1 (PGE1) — a lipid mediator that acts on vascular smooth muscle to produce vasodilation, inhibits platelet aggregation, and maintains patency of the ductus arteriosus in neonates.
According to published clinical literature, Prostaglandin E1 acts on specific EP receptors on vascular smooth muscle cells, producing vasodilation and increasing blood flow to ischaemic tissue. In neonatal medicine, PGE1 prevents closure of the ductus arteriosus by relaxing ductal smooth muscle — a critical mechanism in neonates with ductal-dependent congenital cardiac anomalies.
In peripheral arterial disease, Alprostadil improves microcirculatory blood flow, reduces ischaemic pain, and promotes healing of ischaemic ulcers. In urology, intracavernosal injection produces smooth muscle relaxation in the corpus cavernosum, resulting in penile erection within 5–20 minutes. Full prescribing information is available at the FDA label for Alprostadil, with additional background via the National Cancer Institute and the American Society of Clinical Oncology (ASCO).
According to established neonatal cardiology guidelines, intravenous PGE1 infusion is the universally accepted first-line intervention for maintaining ductal patency in neonates with ductal-dependent congenital cardiac lesions including pulmonary atresia, tricuspid atresia, TGA, HLHS, interrupted aortic arch, and critical aortic stenosis. The American Heart Association and the American Academy of Pediatrics both recognise PGE1 as an essential neonatal resuscitation agent in this context.
Published clinical literature, including studies referenced by the European Society of Cardiology (ESC) guidelines on peripheral arterial disease, supports intravenous Alprostadil infusion for critical limb ischaemia in patients not suitable for revascularisation. Multiple RCTs have demonstrated improvements in rest pain, ulcer healing, and walking distance in patients with Fontaine Stage III–IV PAD.
Supported by guidelines from the European Association of Urology (EAU) and the Urological Society of India (USI), intracavernosal Alprostadil injection is recognised as a second-line treatment for erectile dysfunction with established efficacy in post-prostatectomy, neurogenic, and vasculogenic ED.
| Presentation | Strength |
| Endoprost Injection | 125mcg per vial |
| Endoprost Injection | 250mcg per vial |
| Indication | Strength Typically Used |
| Neonatal ductal-dependent CHD (IV infusion) | 250mcg (dose titrated by weight) |
| Peripheral arterial disease (IV infusion) | 125mcg or 250mcg per cycle |
| Urology — ED (intracavernosal) | Dose determined by urologist |
All dosing is determined by the treating physician. These tables are for reference purposes only.
For detailed indication information refer to NCBI StatPearls — Alprostadil and the European Association of Urology guidelines.
In ductal-dependent congenital heart disease, Endoprost is not elective — it is a lifesaving intervention. Without PGE1 infusion, the ductus arteriosus closes within hours to days of birth, leading to cardiovascular collapse. NICUs must maintain Endoprost as a mandatory emergency drug. A.K. Pharma’s reliable supply ensures your NICU is never without it.
Alprostadil has decades of clinical evidence across neonatal cardiology, vascular surgery, and urology — making it one of the few drugs with genuine multi-specialty application in a hospital formulary.
A.K. Pharma dispatches all Endoprost with temperature-monitored insulated packaging, maintaining the required 2°C–8°C cold chain throughout transit.
As a licensed pharmaceutical distributor in Delhi, A.K. Pharma maintains consistent Endoprost stock, tracks expiry dates, and provides valid GST documentation and institutional purchase order support.
Dosing of Endoprost is determined entirely by the treating physician according to the approved label and clinical context. General administration information from the manufacturer’s prescribing information includes:
Common side effects reported in clinical literature include fever, flushing, hypotension, bradycardia, and apnoea (particularly in neonates). In the PAD indication, local pain at infusion site and oedema are commonly reported.
Apnoea in Neonates: A dose-dependent effect occurring in approximately 10–12% of neonates; respiratory support must be immediately available during infusion per standard NICU protocols.
Hypotension: Vasodilatory effect may produce systemic hypotension, particularly at higher infusion rates; continuous blood pressure monitoring required.
Pyrexia: Fever is a common and recognised effect of PGE1 infusion; monitor and manage per clinical protocol.
Cortical Proliferation of Long Bones: Reported with prolonged PGE1 infusion (typically beyond 120 hours); monitor radiologically if extended infusion is required.
Priapism (Urology Indication): Erection lasting more than 4 hours is a recognised risk with intracavernosal Alprostadil; patients must be counselled on the need for urgent medical attention if this occurs.
Full side effect information is available at FDA Alprostadil Safety Information.
A.K. Pharma stores all temperature-sensitive medicines including Endoprost under manufacturer-recommended cold chain conditions, ensuring product integrity for every supply dispatched across India.
Endoprost (Alprostadil) is manufactured by Bharat Serum and Vaccines, one of India’s leading specialty pharmaceutical and biologicals manufacturers. A.K. Pharma supplies only genuine Endoprost sourced from authorised distributors.
Endoprost (Alprostadil) is used in neonatal ICUs to maintain patent ductus arteriosus in ductal-dependent congenital heart disease, in vascular surgery for critical limb ischaemia and peripheral arterial disease, and in urology for erectile dysfunction refractory to oral therapy. More information at NCBI StatPearls — Alprostadil.
The generic name of Endoprost is Alprostadil (Prostaglandin E1), available in 125mcg and 250mcg injection strengths, manufactured by Bharat Serum and Vaccines.
Alprostadil is temperature-sensitive. Storage outside 2°C–8°C or freezing may compromise the drug’s stability and clinical efficacy. A.K. Pharma maintains cold chain storage and dispatch for every Endoprost order.
Endoprost (Alprostadil) 125mcg and 250mcg injection can be supplied to hospitals, NICUs, and pharmacies across India through licensed pharmaceutical distributors. Contact A.K. Pharma — medicine distributor in Delhi — for availability and pricing.
Endoprost price in India varies by strength and order quantity. Contact A.K. Pharma at 011 4172 6999 or WhatsApp +91 9810034827 for current pricing and institutional supply rates.
You can request a quote directly from this page, call us at 011 4172 6999, or WhatsApp us at +91 9810034827 with your requirements and we will respond promptly.
Yes. A.K. Pharma supplies Endoprost with cold chain-compliant insulated packaging to hospitals and institutions across India including Tier 2 and Tier 3 cities.
Yes. A.K. Pharma supplies Endoprost in bulk to NICUs, hospitals, vascular surgery units, and urology centres across Delhi and India. Contact us for bulk pricing and availability.
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Disclaimer: This page is intended for informational and sourcing/procurement purposes only and does not constitute medical or clinical advice. All treatment decisions, including drug selection, dosing, and administration, should be made by a qualified healthcare professional in accordance with the approved prescribing information. A.K. Pharma is a licensed medicine distributor and does not provide clinical guidance.
