Sodium Hyaluronate 60mg/3mL Single Injection — Viscosupplement for Knee Osteoarthritis Pain Relief
Durolane® (Sodium Hyaluronate) — Single-Injection Viscosupplementation for Knee Osteoarthritis
A Sourcing Guide for Hospitals and Orthopaedic Clinics
Durolane® is a non-animal stabilised hyaluronic acid (NASHA) viscosupplement indicated, according to its approved labelling, for the treatment of pain associated with osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacological therapy or simple analgesics. As with all intra-articular injection therapies, the decision to administer Durolane rests entirely with the treating orthopaedic specialist or physician, in accordance with the approved label. This page provides sourcing and procurement information for hospitals and clinics, not clinical or treatment guidance.
As both a trusted medicine distributor in Delhi and a licensed pharmaceutical distributor in Delhi, A.K. Pharma supplies genuine Durolane (Sodium Hyaluronate) 60mg/3mL pre-filled syringes to hospitals, orthopaedic clinics, and pharmacies across India, manufactured by Bioventus.
Durolane contains sodium hyaluronate, prepared using a proprietary non-animal stabilised hyaluronic acid (NASHA) cross-linking process, designed to mimic the viscoelastic properties of natural synovial fluid.
Synovial Fluid and Osteoarthritis Pathophysiology:
According to published orthopaedic literature, healthy joints are lubricated and cushioned by synovial fluid, which contains hyaluronic acid as a key structural component providing both lubrication and shock-absorbing viscoelasticity. In osteoarthritis, the quality and concentration of hyaluronic acid within synovial fluid diminishes, contributing to increased friction between joint surfaces, reduced shock absorption, and the pain and stiffness characteristic of the condition.
Durolane’s Mechanism: By replenishing the joint space with a cross-linked, stabilised form of hyaluronic acid, Durolane is intended to restore the lubricating and cushioning properties of healthy synovial fluid, according to the manufacturer’s published information. The NASHA cross-linking process is designed to increase the residence time of the hyaluronic acid within the joint compared to non-stabilised formulations, supporting a single-injection treatment approach rather than the multi-injection courses associated with some other hyaluronic acid products.
Full product information is available via the manufacturer’s Bioventus Durolane resource, with additional background on osteoarthritis management available via the American Academy of Orthopaedic Surgeons and the Arthritis Foundation.
Single-Injection Efficacy Data
According to data referenced by the manufacturer, Durolane has been studied in comparison to multi-injection hyaluronic acid regimens, with published data indicating comparable pain relief outcomes to certain 5-injection viscosupplementation courses, while requiring only a single intra-articular injection. Clinical experience cited by the manufacturer indicates that a meaningful proportion of patients report improved quality of life as early as 2 weeks following injection.
Extended Symptom Relief Duration
Published clinical information indicates that a single Durolane injection can provide knee osteoarthritis pain reduction for up to 26 weeks in some patients, though individual response duration varies based on disease severity and other patient-specific factors.
For broader clinical guidance on viscosupplementation and osteoarthritis management, the Osteoarthritis Research Society International (OARSI) publishes ongoing treatment guidelines.
Durolane is supplied as:
| Presentation | Strength | Pack |
|---|---|---|
| Durolane Pre-Filled Syringe | 60mg/3mL (20mg/mL) | Single-dose 3mL glass syringe |
Durolane is administered as a single intra-articular injection, distinguishing it from viscosupplement products requiring a multi-injection course.
Osteoarthritis of the Knee:
For detailed indication information refer to MedlinePlus Osteoarthritis and the CDC Osteoarthritis resource.
Single-Injection Convenience
Unlike multi-injection viscosupplementation courses that require several clinic visits over consecutive weeks, Durolane is designed for administration as a single injection, reducing the treatment burden for patients and clinics alike.
Extended-Duration Symptom Relief
Clinical information cites pain reduction lasting up to 26 weeks following a single injection in some patients, offering an extended treatment interval compared to some alternative options.
Non-Animal Derived Formulation
The NASHA manufacturing process uses a non-animal source, which the manufacturer notes minimises the risk of allergic reactions associated with animal-derived hyaluronic acid products.
Well-Established Safety Profile
As a naturally occurring joint component delivered via a well-established intra-articular injection technique, Durolane has an established tolerability profile across long-term clinical use.
Administration of Durolane is performed by a qualified healthcare professional. General information from the manufacturer’s product materials includes:
Precautions During Administration:
Full administration guidelines are available in the manufacturer’s official product labelling and should always be followed exactly as directed by the treating physician.
Durolane is administered by orthopaedic specialists, rheumatologists, and physicians experienced in intra-articular injection procedures for:
Durolane is administered exclusively in a clinical setting. A.K. Pharma supplies Durolane to hospitals and orthopaedic clinics across Delhi and India.
Common side effects reported include injection site reactions such as swelling, pain, and redness, along with general joint swelling and pain following administration.
Precautions include:
Contraindication in Joint or Skin Infection: Durolane should not be injected in patients with a knee joint infection or infection/skin disease at or near the injection site.
Hypersensitivity: Patients with known hypersensitivity or allergy to sodium hyaluronate preparations should not receive Durolane.
Post-Injection Activity Restrictions: Patients are typically advised to avoid strenuous activity, high-impact sports, and prolonged weight-bearing or standing for a period following injection, per standard post-injection guidance.
Full side effect information is available via the manufacturer’s official Durolane product information.
As a responsible medicine distributor in Delhi, A.K. Pharma stores all orthopaedic products including Durolane under manufacturer-recommended conditions ensuring product integrity for every supply.
Durolane is manufactured by Bioventus (originally developed by Q-Med). It is used by clinicians and patients across numerous countries for single-injection knee osteoarthritis treatment. A.K. Pharma supplies only genuine Durolane sourced from authorised distributors. Learn more about Bioventus’s orthopaedic portfolio directly from the manufacturer.
Q. What is Durolane used for?
Durolane (Sodium Hyaluronate) is used to treat pain associated with osteoarthritis of the knee in patients who have not responded adequately to conservative therapy or simple analgesics, administered as a single intra-articular injection.
Q. What is the active ingredient and strength of Durolane?
Durolane’s active ingredient is sodium hyaluronate, supplied at a strength of 60mg/3mL (20mg/mL) in a single-dose pre-filled syringe, manufactured by Bioventus.
Q. How is Durolane different from multi-injection hyaluronic acid treatments?
Durolane is formulated using a cross-linking process (NASHA) intended to increase the residence time of hyaluronic acid within the joint, allowing for single-injection treatment, whereas some other hyaluronic acid products require a course of multiple injections over consecutive weeks.
Q. How long does pain relief from Durolane typically last?
Published clinical information indicates pain reduction can last up to 26 weeks following a single injection in some patients, though individual results vary.
Q. Is Durolane available in India?
Durolane can be supplied to hospitals and orthopaedic clinics across India through licensed pharmaceutical distributors. Contact A.K. Pharma — medicine distributor in Delhi and pharmaceutical distributor in Delhi — for availability and pricing.
Q. What is the price of Durolane in India?
Durolane price in India varies by order quantity. Contact A.K. Pharma at 011 4172 6999 or WhatsApp +91 9810034827 for current pricing and bulk supply rates.
Q. How to order Durolane from A.K. Pharma?
You can request a quote directly from this page, call us at 011 4172 6999, or WhatsApp us at +91 9810034827 with your requirements and we will respond promptly.
Q. Does A.K. Pharma supply Durolane in bulk?
Yes. A.K. Pharma supplies Durolane in bulk to hospitals and orthopaedic clinics across Delhi and India.
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📱 WhatsApp: +91 9810034827
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Disclaimer: This page is intended for informational and sourcing/procurement purposes only and does not constitute medical or clinical advice. All treatment decisions, including drug selection and administration, should be made by a qualified healthcare professional in accordance with the approved product labelling. A.K. Pharma is a licensed medicine distributor and does not provide clinical guidance.
